α-Helical coiled-coil peptide materials for biomedical applications
نویسندگان
چکیده
منابع مشابه
Sequence Conservation in Plasmodium falciparum α-Helical Coiled Coil Domains Proposed for Vaccine Development
BACKGROUND The availability of the P. falciparum genome has led to novel ways to identify potential vaccine candidates. A new approach for antigen discovery based on the bioinformatic selection of heptad repeat motifs corresponding to alpha-helical coiled coil structures yielded promising results. To elucidate the question about the relationship between the coiled coil motifs and their sequence...
متن کاملNew currency for old rope: from coiled-coil assemblies to α-helical barrels.
α-Helical coiled coils are ubiquitous protein-protein-interaction domains. They share a relatively straightforward sequence repeat, which directs the folding and assembly of amphipathic α-helices. The helices can combine in a number of oligomerisation states and topologies to direct a wide variety of protein assemblies. Although in nature parallel dimers, trimers and tetramers dominate, the pot...
متن کاملRapid Identification of Malaria Vaccine Candidates Based on α-Helical Coiled Coil Protein Motif
To identify malaria antigens for vaccine development, we selected alpha-helical coiled coil domains of proteins predicted to be present in the parasite erythrocytic stage. The corresponding synthetic peptides are expected to mimic structurally "native" epitopes. Indeed the 95 chemically synthesized peptides were all specifically recognized by human immune sera, though at various prevalence. Pep...
متن کاملMaterials for Biomedical Applications
International customers, please contact your local Sigma-Aldrich office. For worldwide contact information, please see back cover. Material Matters is also available in PDF format on the Internet at sigma-aldrich.com/matsci. Aldrich brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldr...
متن کاملStructural plasticity of helical nanotubes based on coiled-coil assemblies.
Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved. However, the path through which such divergence has taken place is usually not known. We have designed two synthetic 29-residue α-helical peptides, based on the coiled-coil structural motif, that spontaneously self-assemble i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
سال: 2016
ISSN: 1939-5116
DOI: 10.1002/wnan.1424